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Kartik Chandran, Ph.D.

Professor, Microbiology & Immunology

Harold and Muriel Block Faculty Scholar in Virology

COVID-19, Ebola, and emerging virusesAntibody-based therapiesAnti-viral therapeuticsVirus-host interactions

A recognized expert on emerging viruses, Dr. Chandran studies how viruses infect cells, and his research seeks to translate this knowledge into new antibody-based therapies. In 2020, Dr. Chandran helped lead Einstein’s research on COVID-19: Within weeks of the global outbreak, his laboratory created a “surrogate” coronavirus that allows scientists at Einstein and elsewhere to more safely study the virus. He also helped develop an antibody test for SARS-CoV-2 that is used clinically at Montefiore Health System and by researchers leading a convalescent plasma clinical trial. read more...

Jill P. Crandall, M.D.

Professor, Department of Medicine (Endocrinology)

Jacob A. and Jeanne E. Barkey Chair in Medicine

Chief, Division of Endocrinology

Director, Fleischer Institute for Diabetes and Metabolism

DiabetesType 2 diabetesDiabetes prevention

Clinical TrialsPrediabetesResveratrol

An expert in diabetes prevention, Dr. Crandall is director of the Diabetes Clinical Trials Unit at Einstein and Montefiore and a principal investigator for several NIH-sponsored clinical trials, including the Diabetes Prevention Program Outcome Study (for which she holds several national leadership positions, including Executive Committee membership), Glycemia Reduction Approaches in Diabetes (GRADE) and the PERL (Preventing Early Renal Loss) study. read more...

Betsy Herold, M.D.

Professor, Harold and Muriel Block Chair, Pediatrics

Professor, Microbiology & Immunology

Professor, Obstetrics & Gynecology and Women’s Health

Vice Chair, Research, Pediatrics, Einstein and the Children’s Hospital at Montefiore (CHAM)

Chief, Division of Pediatric Infectious Diseases, Einstein and CHAM

Infectious diseasesHerpes simplex virusesCOVID-19 and pediatricsVaccines and antiviralsHIV

Dr. Herold directs a translational research program focused on the interactions between viruses and their host and using that knowledge to develop novel treatment and prevention strategies. Through her basic science studies, Dr. Herold has developed a unique candidate vaccine to prevent herpes simplex virus (HSV) infections, which is being advanced for phase I clinical trials. Studies of this vaccine uncovered a previously unappreciated immune evasion strategy; this knowledge may accelerate the development of drugs to bolster vaccine and monoclonal antibody efficacy against a range of pathogens.

Her studies on HIV focus on the development of safe and effective pre-exposure prophylactic strategies for young women and on investigating how HSV interacts with HIV to reactivate HIV. Dr. Herold's team also has discovered a previously unrecognized phenomenon in cell biology in which HSV and other viruses activate a mechanism that helps them gain entry and infect healthy cells. This provides a novel target for the development of new antiviral drugs.

Most recently, her lab has studied why children respond differently and are relatively protected from severe COVID-19. Defining the differences in the immune response in children compared to adults will provide insights into protective immunity against this virus and future pandemic viruses.

Her clinical research focuses on infections in pediatric transplant recipients. Dr. Herold helped established and is co-chair of the Pediatric Infectious Diseases Society Transplant Research Network (PIDTRAN), which supports and promotes projects to prevent and treat infectious diseases among child transplant recipients. Dr. Herold has served on the Office of AIDS Research Advisory Council and on the Pediatric Infectious Diseases Society Council. She has been continuously funded by the NIH since 1989. Dr. Herold has over 180 publications in peer-reviewed journals and has presented her work internationally.